2008-02-07

2017-10-01

We conclude that immunohistochemistry for SATB2 can be used as an additional marker with similar sensitivity and specificity as CK20 for the diagnosis of Merkel cell carcinoma, suggesting a clinical utility in difficult cases where MCC is suspected. SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary.Here we performed immunohistochemical staining SATB2 in 70 MKTs of various origins (stomach 27, colorectum 13, appendix 20 including 19 metastatic adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly 2016-04-01 · Next, we looked at neuronal fate determination in the remaining neuronal populations utilizing layer-specific markers. Satb2 and Cux2 expression. Neurons in the upper cortical layers were defined by their immunoreactivity for Satb2+ (known to be expressed in L2, L3, L4, and L5; Fig. 2a–h) and Cux2 (normally expressed in L2 und L3, Fig. 2i–p) [12, 14–16, 20, 21].

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Cortical layer markers are useful tools for studying the development, functional neuroanatomy and pathology of the cerebral cortex. The cerebral cortex is organized into six layers of both morphologically and functionally divergent neurons. The different layers can be identified using antibodies against protein markers expressed in specific layers. 2018-02-01 · Abstract.

The cerebral cortex is organized into six layers of both morphologically and functionally divergent neurons.

Satb2 is colocalized with specific layer markers in the neocortex. (A‐A″′) Double immunostaining of Satb2 (green) and Brn2 (red) in the layers II–III shows that most of Satb2‐positive cells are also Brn2‐positive (arrows), but there are a few cells labeled with only Satb2 (double arrowheads) or Brn2 (arrowheads).(B‐B″′) Double labeling of Satb2 (green) and Cux1 (red) in the

SATB2 was shown to be almost exclusively expressed in colorectal carcinoma (3). This observation was followed by validation using colorectal cancer tissue from 9 different research cohorts (155 8 localized and 252 metastatic colorectal adenocarcinoma).

markers such as SATB2 and PAX8.(5-7) SATB2 (special AT-rich sequence-binding protein 2) is a transcriptional regulator (encoded on chromosome 2q32-33) that is involved in osteoblastic and cortical neuron differentiation and in skeletal development.(8) SATB2 is also expressed in epithelial cells of the lower GI tract

ISH of the layer 5 marker Er81 ( Figures 7 D and 7H) and layer 4 marker RoRβ (data not shown) showed that their expression domains were not altered in E15.5 and E17.5 mutant brains; Fezf2 expression was also not affected by the Satb2 mutation (data not shown). Cortical layer markers are useful tools for studying the development, functional neuroanatomy and pathology of the cerebral cortex. The cerebral cortex is organized into six layers of both morphologically and functionally divergent neurons. The different layers can be identified using antibodies against protein markers expressed in specific layers. 2018-02-01 · Abstract.

MATERIALS AND METHODS: Seven ITACs, 66 non-ITACs, and 1 case of extensive intestinal metaplasia (IM) of the nasal mucosa were included in the study and stained with SATB2, CK20, CDX2, and CK7 antibodies. SATB2 is a transcriptional regulator involved in osteoblastic and neuronal differentiation and is a sensitive and specific marker of colorectal epithelium.
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SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid. SATB2 is a nuclear matrix-associated transcription factor and epigenetic regulator that is involved in osteoblastic differentiation and is also expressed in the glandular epithelial cells of the lower gastrointestinal tract. Recent studies have shown that, because of its relative specificity for ost … SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors Special AT-rich sequence binding protein-2 (SATB2) is selectively expressed in the lower gastrointestinal tract mucosa and has been identified as a sensitive marker for colorectal adenocarcinomas.

The expression of SATB2 was also found to activate β‐catenin pathway which is highly activated in most cancers. Inhibition of SATB2 in CSCs suppresses cell proliferation, colony and spheroid formation in suspension, and EMT characteristics. SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized … 2016-09-01 2010-07-12 Definition: Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene..
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29 Nov 2016 The genome-organizer Satb2 has a key role in memory formation by marker Wfs1 (Figure 1E) and the cortical layer markers Cux1, Ctip2, 

Hela genommetyleringsuppsättningar avslöjar nedreglering av IGFBP6 och SATB2  Insatser för RELN / TBR1 och SATB2 / POU3F2 visar förstorade områden i bilden. Bottom panel shows temporal phases of neuronal and glial markers derived  Important osteogenic marker ALP activity was determined by a quantitative ALP 4C, the expression levels of Ostrix, SATB2 and Runx2 were repressed by the  Satb2 determines miRNA expression and long-term memory in A novel distributed optic fiber transduser for landslides Frontiers | Advances in mt-tRNA  SATB2 has gained interest as a relatively specific marker of colorectal differentiation, with potential applications including determining origin of adenocarcinomas of unknown primary and distinguishing primary ovarian mucinous adenocarcinomas from colorectal metastases.